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The biotech sector enters April under significant stress. XBI remains in a pronounced downtrend, and broad market volatility has bled heavily into small-cap names — particularly those approaching binary catalysts. Most featured candidates this week are sitting at or near oversold levels, with eight of ten showing negative 21-day momentum. That
Alzheimer's Disease
When the thesis changes, the position has to change with it.
Biotech Investing
The FDA just approved the first oral IL-23 blocker for psoriasis — a structural break in immunology that lands precisely when Big Pharma's patent cliff desperation is making de-risked clinical assets more valuable than ever.
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Biotech is caught in a crossfire this week. Escalating geopolitical tensions in the Middle East have injected fresh volatility across risk assets, with small-cap biotech taking an outsized hit as institutional capital rotates toward safe havens. The sell-the-sector trade doesn't discriminate between companies burning cash and those sitting
Scanner
Biotech just gave back three weeks of gains in a single session. XBI dropped to $122.62 — virtually unchanged from where it started the year — after a broad risk-off move that hit small-caps harder than large-cap pharma. The catalyst? Rising yields, tariff escalation noise, and a general loss of patience
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63% of our scanner picks gained 15%+ within 45 days. Here's the full breakdown across 17 weeks.
Autoimmune
Big Pharma is betting $10B+ that T-cell engagers can reboot the immune system. Here's the science, the money trail, and the biotechs worth watching.
Obesity
Zealand ($ZEAL) Pharma's petrelintide posted among the cleanest safety profiles ever seen in an obesity trial. The market punished it 35%. The data deserves a closer look.
Biotech enters the second week of March in a turbulent crosscurrent. The XBI ETF trades near $120–126, up roughly 2–4% year-to-date after a blistering 36% return in 2025 — but the first week of March has tested nerves hard. A dramatic escalation in the Middle East, with US-Israeli strikes
Finding Undervalued Biotechs via Thorough Investigation and Sharing Tips
(Editor's note) The evolving geopolitical landscape in the Middle East warrants close attention from market participants. Elevated volatility may pressure near-term returns; however, it can also open selective opportunities for investors with appropriate risk tolerance and a long-term perspective. Above all, we stand in solidarity with those directly
Three months ago, we called INAB a "tier-one scientific innovator trapped in a tier-four financial vehicle." Since then, the company has raised $20 million, appointed a new President, and quietly unveiled what may be its most valuable asset. Here's what's changed — and what hasn't.
(Editor's note : I'm releasing the Week 4 Scanner a bit early, as I'm currently tied up with a new project at work. A quick heads-up on something not covered in this week’s issue: MoonLake Immunotherapeutics ($MLTX) is hosting its Investor Day on February
(Editor's note) I would like to remind readers that this scanner is designed to provide preliminary leads and spark ideas for further analysis. While our platform leverages historical data, machine learning, and AI-driven insights, predictive modeling is inherently uncertain. Please conduct thorough independent research before making any investment
I apologize for the delay in providing this week’s scanner result due to my travel commitments. Small-cap biotech continues its brutal selloff as sector rotation accelerates into large-cap pharma. The XBI closed the week down 3.2%, extending its drawdown to -18% year-to-date as risk appetite evaporates ahead of
The biotech sector is entering February with mixed signals. XBI traded at $120.23, down 1.06% on the day, pulling back from recent highs near $131. After a strong 2025 finish that saw the equal-weighted biotech ETF surge nearly 37% year-to-date by December, January 2026 has brought profit-taking and
The biotech sector enters Q1 2026 with renewed optimism as XBI hovers around $120-131, digesting strong 2025 gains that saw the equal-weight ETF outperform the broader health sector. Dealmaking chatter continues to drive sentiment, with Mizuho analysts pointing to sustained M&A activity as big pharma fills pipelines through
Last week's 44th annual J.P. Morgan Healthcare Conference closed with a whimper rather than a bang. The industry's premier gathering—where mega-deals typically set the tone for the year—delivered what prominent biotech investor Brad Loncar called "the slowest JPM for news in a
Takeover Rumors Swirl Around Revolution Medicines and Abivax as Industry Giants Hunt for Blockbusters The 44th Annual J.P. Morgan Healthcare Conference officially begins today, January 12, 2026, setting the stage for what analysts are already calling a "banner year" for biopharma M&A. The dealmaking atmosphere
And it wasn't a very good idea!
After a jam-packed December 2025, we enter the second week of 2026 with a sharply divided biotech market. While the XBI struggles to find its footing, our scanner has identified a distinct bifurcation: a cluster of “Pressure Cooker” setups—micro-caps with shrinking cash runways colliding with near-term data—versus well-capitalized
As we approach the end of the year, I want to take a moment to wish all our subscribers a very Merry Christmas and a Happy New Year. It has been a year of navigating the volatile biotech markets together, and I truly appreciate the community of independent-minded investors we&
